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Velpanat is a pan-genotopic treatment for Chronic Hepatitis C (HCV), meaning it can be used to treat chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection. It is a fixed-dose combination of sofosbuvir (a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor) and Velpatasvir (an HCV NS5A inhibitor).Dosage and Administration
Velpanat Each tablet contains 400mg of Sofosbuir and 100mg of Velpatasvir.
In most cases, you will take one tablet of Velpanat each day for a period of 12 weeks. This dosage may need to be adjusted in patients with renal impairment or renal disease.
Velpanat is taken alone in cases without cirrhosis or with compensated cirrhosis (Child-Pugh A). Velpanat is used in combination with ribavirin in cases with decompensated cirrhosis (Child-Pugh B and C).Side effects
The most common side effects of Velpanat are headache and tiredness. If taken in combination with ribavirin other common side effects are anemia, nausea, insomnia, and diarrhea.
When Velpanat is used in combination with medicines containing amiodarone it can lead to serious side effects including slowing of the heart rate. This can result in death or need of a pacemaker. If you are taking these medicines in combination, tell your doctor immediately if you notice fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.Precautions
Prior to taking Velpanat, make sure you tell your doctor of any medical conditions you have (especially any other liver problems or kidney problems). Tell your doctor if you are pregnant or trying to become pregnant, or if you are breastfeeding or planning to breastfeed.Velpanat can can unwanted interactions with some other medicines. Make sure to tell your doctor of all medicines you are taking including prescription and over-the-counter medicines, vitamins, and herbal supplements. Or particular importance are any products containing tenofovir disoproxil fumarate or amiodarone.